Through the looking glass of cryoEM unveils the unique molecular structure and camouflaging sugar coating of feline coronavirus surface spike protein
2020-01-16 | ACADEMIA SINICA
The recent outbreak of severe acute respiratory syndrome (SARS), the Middle East respiratory syndrome (MERS), and the severe pig pandemics caused by the emerging porcine coronavirus, remind us how infection by coronaviruses can impact our health and socioeconomics. Coronaviruses also infect cats and cause feline infectious peritonitis (FIP). Due to the difficulty of diagnosis and the lack of effective treatment and prevention methods, once a cat is infected with the virus that causes the most prevalent serotype 1 cat infectious peritonitis, there is no effective treatment, and the fatality rate is almost 100%. It, therefore, poses an urgent issue for veterinarians.